| |
SKi Sensors are available in both flow cell and multiwell probe formats. Both probe and flow cell utilize identical nanoporous silicon biosurfaces and surface chemistries for enhanced data consistency. |
| |
 |
 |
| |
SKi Sensor™ Flow Cell: fo real time kon, koff, kD kinetic characterization.
|
SKi Sensor™ Multiwell Probe: For affinity ranking, concentration and end-point determination measurements. |
| |
- Regeneratable
- Dual channel, self-referenced flow cell
- Disposable fluidics in flow cell
- Now available: dual flow cell
- Available in 2010: 24 flow cell upgrade
|
- 8 wells in parallel
- Up to 96 wells
- AutoHandler automates probe movement
- Regeneratable, disposable
|
Surface Chemistries
3D surfaces for all SKi Sensor™ chips are prepared to have extremely low non-specific binding. Complex biological fluids like plasma can be used without deleterious effects.Covalent chemistries currently available:
- Benzalydehyde Chip: Does not require an activation step. Protein is crosslinked offline with stoichiometric amount of linker, then conjugated to the surface.
- Carboxyl Chip: Amine-coupling.
Non-covalent chemistries currently available:
|
| |
- Streptavidin Chip: For biotinylated proteins, peptides and ligands
- NTA-Ni Chip for polyhistidine - tag applications
- Protein A Chip for immunoglobulin capture
- Protein G Chip for immunoglobulin capture
Silicon Kinetics has also developed procedures for covalent stabilization of indirectly-captured ligands.
|
| NEW |
| NEW |
| NEW |
| |
| |
|
