Ski Sensors™

SKi Sensors are available in both flow cell and multiwell probe formats. Both probe and flow cell utilize identical nanoporous silicon biosurfaces and surface chemistries for enhanced data consistency.

SKi Sensor™ Flow Cell: fo real time k_on, k_off, k_D kinetic characterization.

SKi Sensor™ Multiwell Probe: For affinity ranking, concentration and end-point determination measurements.

Regeneratable
Dual channel, self-referenced flow cell
Disposable fluidics in flow cell
Now available: dual flow cell
Available in 2010: 24 flow cell upgrade

8 wells in parallel
Up to 96 wells
AutoHandler automates probe movement
Regeneratable, disposable

Surface Chemistries

3D surfaces for all SKi Sensor™ chips are prepared to have extremely low non-specific binding. Complex biological fluids like plasma can be used without deleterious effects.

Covalent chemistries currently available:

Benzalydehyde Chip: Does not require an activation step. Protein is crosslinked offline with stoichiometric amount of linker, then conjugated to the surface.
Carboxyl Chip: Amine-coupling.

Non-covalent chemistries currently available:
	Streptavidin Chip: For biotinylated proteins, peptides and ligands NTA-Ni Chip for polyhistidine - tag applications Protein A Chip for immunoglobulin capture Protein G Chip for immunoglobulin capture Silicon Kinetics has also developed procedures for covalent stabilization of indirectly-captured ligands.
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